Work

Synthetic Applications of Hypervalent Iodine Reagents in Multicomponent Reactions

Year: 2026

Type: article

Abstract: Multicomponent reactions (MCRs) provide an efficient strategy for the rapid assembly of structurally diverse molecules from simple starting materials in a one‐pot manner. Meanwhile, hypervalent iodine reagents have emerged as versatile and environmentally benign reagents owing to their unique oxidative properties and diverse activation modes. The merger of hypervalent iodine chemistry with MCRs has enabled numerous efficient transformations involving oxidative activation, radical relay processes, electrophilic group transfer, and carbynoid chemistry. This review summarizes recent advances in hypervalent iodine‐mediated MCRs involving acyclic iodine(III) reagents, cyclic hypervalent iodine reagents, diaryliodonium salts, and iodine(V) reagents.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70803

Authors: Jialiang Wu, Yanbing Ji, Jiaxin He, Meiling Tian, Yunfei Du

Institution: Tianjin University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Graduate Research and Innovation Projects of Jiangsu Province, National Key Research and Development Program of China

Awards: 高价碘化物/DMSO介导下含硫杂环化合物的合成新方法研究, G7110715537, G7226114419, G8028932987