Work

#171 - Dietary Inflammatory Index Profile in Patients With Masld

Year: 2026

Type: article

Abstract: Introduction and Objectives Dietary characteristics have been identified as predictors of disease progression in Metabolically Dysfunctional-Associated Steatotic Liver Disease (MASLD). The Energy-adjusted Dietary Inflammatory Index (E-DII) quantifies the inflammatory characteristics of habitual diet. Objective: To evaluate the E-DII in patients with MASLD, according to the presence of overweight and obesity. Materials and Methods Cross-sectional study conducted on patients aged 18-45 years. Diagnosis of MASLD was made according to current criteria, with steatosis assessed by transient elastography. Patients were classified by body mass index (BMI) into four groups: Overweight + MASLD; Overweight Non-MASLD; Obesity + MASLD; and Obesity Non-MASLD. The frequency of food intake was assessed using the SNUT questionnaire, and 30 dietary parameters were selected to calculate the E-DII. Results 437 patients were included, 62.2% (n=285) were men. The E-DII median was 6.6 [5.9-7.3], indicating a generally pro-inflammatory profile; however, no significant differences were observed in the analyses of individual parameters. MASLD groups had a higher pro-inflammatory score (6.67 vs. 6.33, p=0.003), with higher carbohydrate intake (200g vs. 170g, p=0.004) and lower vitamin D intake (124 IU vs. 159 IU, p=0.006). Patients with Obesity + MASLD had a significantly higher E-DII (6.80±0.95) than other groups (p0.05), whereas Overweight non-MASLD patients had a significantly lower E-DII (6.1±1.2, p0.05). No significant differences were observed between the non-MASLD patient groups regardless of BMI. Figure 1 shows the E-DII profile. Conclusions Patients with obesity and MASLD have a significantly higher pro-inflammatory dietary profile. The differences could be attributed to a deficiency of anti-inflammatory components in the diet.

Source: Annals of Hepatology

DOI: 10.1016/j.aohep.2026.102405

Authors: Karen Sacal-Saba, Martha Ramos-Ostos, Graciela Castro-Narro, Iván López-Méndez, Eva Juárez-Hernández

Institutions: Universidad Anáhuac, Hospital Médica Sur

Language: English

Topic: Nutritional Studies and Diet

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500