#158 - Familial Risk of Fibrotic Steatotic Liver Disease in First-degree Relatives of Individuals With Advanced Fibrosis in Latin America
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction and Objectives In Latin America, the familial risk of liver fibrosis in steatotic liver disease (SLD) remains poorly characterized. This multinational study aimed to assess the familial risk of liver fibrosis across SLD subtypes in the region. Materials and Methods Cross-sectional analysis of prospectively enrolled adults with SLD (2023 criteria) at 16 tertiary centers in seven countries (2024–2026). We recorded a family history of advanced fibrosis in first-degree relatives. Fibrosis was assessed by liver biopsy or vibration-controlled transient elastography (VCTE) when biopsy was unavailable (significant fibrosis: biopsy F2 or VCTE 8 kPa; advanced fibrosis: biopsy F3 or VCTE 12 kPa). We used logistic regression to model the association of family history of advanced fibrosis with liver fibrosis, adjusting for age, sex, ethnicity, body mass index (BMI), type 2 diabetes mellitus (T2DM), and SLD subtype. Results We included 592 participants (median age 59 [50–66] years; 50.8% women). Among these, 79.7% had MASLD, 8.3% MetALD, and 12.0% ALD. The prevalence of significant and advanced fibrosis was 40.2% and 32.0%, respectively. A total of 20.4% had a first-degree relative with advanced fibrosis. In the models adjusted for demographic, metabolic, and SLD subtype factors, family history was independently associated with higher odds of significant fibrosis (aOR:1.83, 95%CI:1.13–2.96; p=0.014) and advanced fibrosis (aOR:1.76, 95%CI:1.06–2.93; p=0.030)( Figure ). Conclusions In this multinational Latin American cohort of adults with SLD, family history of advanced fibrosis in first-degree relatives was frequent and associated with a higher prevalence of both significant and advanced fibrosis (FONDECYT 1241450).
Source: Annals of Hepatology
Authors: Luis Díaz, Francisco Idalsoaga, Mario Pessoa, Claudia Oliveira, Patricia Zitelli, Scherezada Mejía-Loza, Ezequiel Ridruejo, Mirta Peralta, Cesar Castro, Jorge Garavito, Rommel Zambrano, Gustavo Ayares, Nancy Solis, María Orellana, Francisco Barrera, Sebastián Marciano, Adrian Gadano, Jorge Martínez, María Acosta, Martín Tagle, Hugo Cedron, Ismael Yepes, Dalis Pérez, María Saavedra, Samuel Pérez, Ignacio García, Orfanel Pineda, Liz Toapanta, Aline Sorribas, Manuel Mendizabal, Lorena Castro, Loreto Aguilar, Samantha Wu, Catalina Roa, Fabiana Nina, Estefania Liza, Javier Díaz, Roberto Pérez, María Martinez, Natalie Vilcinskas, Daniza Contreras, Daniela Simian, Juan Roblero, Pamela Gil, Arun Sanyal, Juan Arab, Marco Arrese
Institutions: Pontificia Universidad Católica de Chile, Universidade de São Paulo, Hospital Juárez de México, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Hospital Muñiz, Hospital Italiano de Buenos Aires, Universidad Peruana Cayetano Heredia, Universidad de Cartagena, Clínica CES, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Hospital Universitario Austral, Universidad de Los Andes, Chile, Universidad del Alba, National University of San Marcos, Instituto Nacional de Diabetes, Endocrinología y Nutrición, Hospital Clínico de la Universidad de Chile, University of Chile, Virginia Commonwealth University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W7204249402