Iron‐Catalyzed Thiocyanation of Heterocycles and Aromatics Utilizing a Combination of NH 3 ·H 2 O and CS 2
Year: 2026
Type: article
Abstract: ABSTRACT In this study, we report the iron‐catalyzed thiocyanation of heterocycles and aromatics using NH 3 ·H 2 O and CS 2 as the SCN source with (NH 4 ) 2 S 2 O 8 as an oxidant at room temperature. A string of heterocycles and aromatics, including indoles, pyrroles, anilines, pyrazols, and anisoles, are readily accommodated under environmentally benign conditions. The protocol provides access to various thiocyanated products bearing electron‐deficient/‐rich substituents at different positions in moderate to excellent yields. Mechanistic studies reveal the reaction probably proceeds via a radical process.
DOI: 10.1002/ajoc.70535
Authors: Jun‐Fa Pang, Zan Chen, Jiarong Mai, Mengting Bai, Ganwen Xue, Huiting Zhou, Libo Nie, Huishi Guo, Yin‐Long Lai
Institutions: Shaoguan University, Hunan University of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7204251705