Work

NAD + or β-hydroxybutyrate each protects against tachypacing-induced metabolic remodeling through regulation of mitophagy in HL-1 cardiomyocytes

Year: 2026

Type: article

Abstract: Nicotinamide adenine dinucleotide and β-hydroxybutyrate restore mitochondrial function and metabolic balance, in part by preserving PINK1-Parkin-MFN2-mediated mitophagy. Silencing key mitophagy regulators abolishes these protective effects, identifying mitophagy as a central mechanism linking metabolic interventions to functional recovery and as a potential therapeutic target in atrial fibrillation-associated remodeling.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00253.2026

Authors: Xi Qi, Liangyu Hu, Alexia van Rinsum, Werner J. H. Koopman, Jaap Keijer, Deli Zhang

Institutions: Wageningen University & Research, Radboud University Medical Center

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: China Scholarship Council