Work

Optimization of the procedure for preparation of biopolymeric nanoparticles as carriers of P60 antitumor peptide

Year: 2026

Type: article

Abstract: P60 is a synthetic peptide that binds to forkhead box P3 (FOXP3), inhibiting its activity, and therefore can be implemented in cancer immunotherapies. However, the peptide is characterized by low in vivo stability, poor selectivity, and rapid systemic clearance. Thus, the present study evaluates the possibility of overcoming these limitations by its encapsulation in two types of nanoparticles, specifically chitosan-alginate and chitosan-albumin nanoparticles. The developed nanoparticles possessed optimal physicochemical properties. However, the chitosan-albumin nanoparticles were characterized by higher loading of the peptide. The loading degree of P60 was higher in the chitosan-albumin nanoparticles than in the chitosan-alginate nanoparticles. Faster release in media with a slightly acidic pH was registered for both systems, which was considered an important prerequisite for the selective delivery of the loaded peptide to tumor tissue. In conclusion, both types of the developed biopolymeric nanoparticles can be further evaluated as possible carriers of the peptide.

Source: Pharmacia

DOI: 10.3897/pharmacia.73.e206826

Authors: Lyubomira Radeva, Alejandro Serrano, Maria J. Garrido, Krassimira Yoncheva

Institutions: Medical University of Sofia, Universidad de Navarra

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107