Work

Novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives as potent α-glucosidase inhibitors: synthesis, biological evaluation, and in silico studies

Year: 2026

Type: article

Abstract: Novel diazene-tri(phenoxy-triazole-acetamide) hybrids 9a–p were synthesized as α‑glucosidase inhibitors. The best compound, 9f, acted as a competitive inhibitor, and molecular simulations supported its stable binding mode.

Source: RSC Advances

DOI: 10.1039/d6ra05948a

Authors: Shahab Kermaninia, Mohammad Hosein Sayahi, Mohammad Halimi, Seyedeh Zohreh Mirjalili, Hassan Mohammadi, Amir Ali Abbasi, Somayeh Mojtabavi, Nima Sepehri, Haleh Hamedifar, Bagher Larijani, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi

Institutions: Tehran University of Medical Sciences, Payame Noor University, Islamic Azad University, Babol, Endocrinology and Metabolism Clinical Sciences Institute, CinnaGen (Iran), Alborz University of Medical Sciences, Babol University of Medical Sciences

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funder: Tehran University of Medical Sciences and Health Services

OpenAlex ID: W7204257883

FWCI:

Cites: 26

Cited by:

Related to: