Caffeine and Cardiovascular Responses in Children and Adolescents: Quantitative Analysis and Comparison With Adult Evidence
Year: 2026
Type: dataset
Abstract: This repository contains the statistical analysis and supporting code for a quantitative investigation of cardiovascular responses to caffeine exposure in children and adolescents, with a formal comparison against pooled adult evidence. The analysis examines changes in cardiovascular and haemodynamic parameters following caffeine exposure, including blood pressure, ambulatory blood pressure, arterial stiffness, cardiac efficiency, ventricular–arterial coupling, contractility, and related cardiovascular measures. A key component of the analysis is a formal paediatric versus adult comparison at approximately matched weight-adjusted caffeine doses. Adult estimates were derived from a synthesis of 19 trials involving 385 participants, while paediatric estimates were based on the available paediatric data. The comparison evaluates whether cardiovascular responses in children differ significantly from those observed in adults at comparable doses. The repository also includes analyses examining the internal consistency of pressure-volume loop derived measures, ventricular contractility and arterial load, and directional concordance across cardiovascular domains. Importantly, the analysis explicitly distinguishes internal arithmetic consistency from independent cross-modality validation because blood pressure measurements contribute to the construction of pressure-volume loop measures. The paediatric versus adult analysis found no statistically significant difference between children and adults in the evaluated time bands at matched weight-adjusted doses. This provides a quantitative assessment of whether the available evidence supports the hypothesis that children experience substantially greater cardiovascular responses to caffeine than adults. The repository is intended to promote transparency, reproducibility, and independent evaluation of the statistical analyses underlying the associated research manuscript. Contents R code for statistical analyses Quantitative paediatric cardiovascular response analyses Formal paediatric versus adult comparisons Bayesian sensitivity analysis Cardiovascular domain concordance analysis Internal validation and consistency checks Derived statistical estimates and supporting calculations Data and interpretation The analyses are based on published aggregate-level data. No individual participant-level data are included. Interpretations should therefore be considered in the context of the available published evidence, sample sizes, and assumptions required for deriving standard errors and comparative estimates.
Author: Ahad, Abiya
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204259130