Work

Mathematical modeling of dietary timing- and protein quality-responsive liver circadian clock and its function on ribosome biogenesis

Year: 2026

Type: article

Abstract: This study provides a mechanistic modeling framework linking dietary protein quality, EAA-sensitive mTORC1/GCN2-ISR signaling, peripheral circadian entrainment, and ribosome biogenesis, highlighting how nutrient stress may shape individualized circadian recovery and metabolic regulation.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00152.2026

Authors: Lingjun Lu, Jordan L. Levy, Tracy G. Anthony, Ioannis P. Androulakis

Institution: Rutgers, The State University of New Jersey

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases