Get started
Work

Prognostic factors for outcomes in young and middle-aged stroke patients with atrial fibrillation: a hospital-based cohort study in China

Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Objective: Atrial fibrillation (AF) is a well-established risk factor for ischemic stroke and is associated with substantial mortality and disease burden. This study aimed to evaluate the 3- and 12-month prognosis after stroke in Chinese patients aged < 65 years with AF. Methods: We conducted a hospital-based cohort study and enrolled 230 stroke patients with AF. Clinical characteristics and outcomes at 3 and 12 months after stroke were assessed. Results: The mortality, recurrence, and dependency rates at 3 months after stroke were 13.3%, 5.1%, and 23.1%, respectively, and at 12 months were 17.2%, 19.0%, and 36.8%, respectively. At 3 months, compared with POCI, PACI was associated with 4.79-fold and 2.27-fold increases in the risks of mortality and dependency, respectively. Obesity and current smoking were associated with 3.71-fold and 6.87-fold increases in recurrence risk, respectively (all P < 0.05). At 12 months, compared with POCI, PACI remained associated with 3.10-fold and 3.73-fold increases in mortality and dependency risks, respectively (all P < 0.05). Hypertension was not associated with increased stroke mortality in these young and middle-aged patients with AF (P = 0.122). Conclusions: This study demonstrates that mortality and dependency rates among post-stroke patients increase over time, and that specific stroke subtypes and modifiable risk factors substantially elevate health risks. These findings underscore the need to optimize blood pressure management, prioritize influential risk factors, and develop targeted strategies for the prevention, treatment, and rehabilitation of stroke and atrial fibrillation.
DOI: 10.21203/rs.3.rs-10402485/v1
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W7204277731
Cites: 1
Cited by:
Related to: 10