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Serum and Follicular Fluid Asprosin Levels in Infertile Women: Associations with Ovarian Reserve and IVF/ICSI Outcomes

Year: 2026

Type: article

Abstract: Objective: To investigate the presence of Asprosin in human follicular fluid (FF) and to evaluate its relationship with ovarian reserve, oocyte quality, and clinical pregnancy outcomes in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection. Material and Methods:This prospective cohort study included 63 non-diabetic infertile women.Paired serum and FF samples were analyzed.Patients were stratified according to ovarian reserve (anti-Müllerian hormone) and pregnancy outcomes.Results: Asprosin was detectable in FF at levels comparable to serum (p>0.05), with a significant positive correlation (r=0.382;p=0.002), indicating compartmental equilibrium.However, contrary to animal models, Asprosin levels did not differ significantly across low, normal, or high ovarian reserve groups, nor did they predict clinical pregnancy.Conclusion: Asprosin exists in FF in equilibrium with the systemic circulation.However, endogenous levels do not fluctuate with ovarian reserve status and do not serve as a predictive biomarker for IVF success in non-diabetic women.

Source: Türk Üreme Tıbbı ve Cerrahisi Dergisi

DOI: 10.24074/tjrms.2026.68553