In vivo investigations of antidepressant profile of Moringa oleifera seeds using well established experimental models
Year: 2026
Type: article
Abstract: The petroleum ether (60-80°C) extract, chloroform, methanol, and water extracts of Moringa oliefra seeds were prepared using the repetitive and sequential Soxhlet extraction procedure.Only the chloroform and methanol extracts included more bioactive classes of phytoconstituents, according to the results obtained by preliminary phytochemical study on many crude extracts.Thus, only extracts of chloroform and methanol were tested using well-established models for the antidepressant profile of plant seeds.The only test ingredient among the many extracts of Moringa oliefra seeds that exhibits the strongest significant antidepressant action at a higher dose level of 400 mg/kg is the methanol extract, which is equivalent to the commercially available medication imipramine.For additional purification, the most active biologically methanol extract under current investigations was successively fractionated utilizing solvents in ascending order of increasing polarity, namely n-hexnae, ethyl acetate, and 1-butanol.Only the ethyl acetate fraction, which is the test component, has the strongest significant antidepressant impact among the other fractions of Moringa oliefra seeds at a higher dose level of 50 mg/kg, which is comparable to the commercially available medication imipramine.According to scientific reports, the naturally occurring dietary phenolic compound can be used to treat a number of illnesses, including oxidative stress, microbial infections, liver disorders, heart disorders, inflammatory problems, fever, mental health issues, obesity, viral infections, and hypertension.According to the aforementioned findings, flavonoids and phenols are thought to be the main bioactive components of plant matter.Flavonoids and phenolic chemicals are responsible for the CNS actions of plant material.
Authors: Amanjot Kaur, Puja Gulati, Nidhi Rani
Institutions: Desh Bhagat University, Chitkara University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7204438786