Work

Denominator selection bias in local genetic correlation: closed form, correction and diagnostic

Year: 2026

Type: software

Abstract: LAVA reports a local genetic correlation only where both traits clear a univariate heritability filter at P < 0.05. The filter acts on the denominator of a ratio estimator and biases every surviving estimate. This software derives the bias in closed form, supplies a gate-aware correction and an applicability diagnostic, and validates both against LAVA's own code path across six psychiatric trait pairs.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.22132758

Authors: Jain, Riddhiman, Paquin, Dana

Institution: Stanford University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7204448500

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