Year: 2026
Type: conference-abstract
Abstract: Background/Introduction Normocalcaemic primary hyperparathyroidism (NC-PHPT) is characterized by persistently elevated parathyroid hormone concentrations despite normal total and ionized serum calcium after exclusion of secondary causes of hyperparathyroidism. Although primary hyperparathyroidism has been associated with increased cardiometabolic risk, the metabolic profile of NC-PHPT remains insufficiently defined. Purpose To evaluate the metabolic characteristics of patients with NC-PHPT and compare them with patients with hypercalcaemic primary hyperparathyroidism (HC-PHPT) and healthy controls. Methods This cross-sectional study included 22 patients with NC-PHPT, 21 patients with HC-PHPT, and 22 healthy controls matched for age, sex, and body mass index (BMI). Secondary causes of hyperparathyroidism were excluded in all participants. Anthropometric and metabolic parameters, including BMI, fasting plasma glucose, glycated haemoglobin (HbA1c), total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were assessed. Results Body mass index was comparable between the NC-PHPT and HC-PHPT groups. Mean fasting plasma glucose was higher in the HC-PHPT group than in the NC-PHPT group and healthy controls, with borderline statistical significance. HbA1c did not differ significantly among the three groups. Total cholesterol and LDL cholesterol tended to be higher in patients with NC-PHPT. HDL cholesterol was significantly lower in the HC-PHPT group than in both the NC-PHPT group and healthy controls, whereas no significant difference was observed between patients with NC-PHPT and controls. Triglyceride concentrations were comparable across all groups. Conclusion Patients with normocalcaemic primary hyperparathyroidism may exhibit metabolic alterations similar to those observed in hypercalcaemic primary hyperparathyroidism despite normal serum calcium concentrations, suggesting that NC-PHPT should not be considered a metabolically benign condition.
Institutions: University of Belgrade, Univerzitetski Klinički Centar Srbije
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,292
OpenAlex ID: W7204459719