AMERICCAASS Registry: A Contemporary View of Heart Failure in the Americas
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Heart failure (HF) is a growing global health concern, particularly in low- and middle-income countries. Contemporary, region-specific data from the Americas remain scarce. The AMERICCAASS (Registro Americano de Insuficiencia Cardiaca Ambulatoria o Agudamente Descompensada [American Registry of Ambulatory or Acutely Decompensated Heart Failure]) registry was designed to provide broad, robust regional evidence on HF. METHODS: The AMERICCAASS registry is a prospective, multicenter, observational study including adults with HF enrolled as inpatients or outpatients at 119 institutions in 21 countries across the Americas. Sociodemographic and clinical variables were summarized descriptively. RESULTS: A total of 6732 patients were included; 30.1% were inpatients and 69.9% outpatients. The median age was 68.6 years, and 58.2% were men. Hypertension (69.6%), dyslipidemia (41.6%), and coronary artery disease (39.2%) were the most common comorbidities. Ischemic (39.9%) and hypertensive (17.9%) etiologies predominated, while Chagas disease was present in 3.4%. Unhealthy habits were common, with 39.8% reporting smoking, 24.4% alcohol use, and only 23.9% regular physical activity. New York Heart Association class III predominated in inpatients (45.2%), whereas New York Heart Association class II predominated in outpatients (52.6%). HF with reduced left ventricular ejection fraction was the most common phenotype in both settings: inpatients (56.8%) and outpatients (55.0%). β Blockers and mineralocorticoid receptor antagonists were the most frequently prescribed therapies, followed by sodium-glucose cotransporter-2 inhibitors. Among inpatients, intensive care unit admission occurred in 55.9%, and the in-hospital mortality rate was 7%. CONCLUSIONS: The AMERICCAASS registry offers a comprehensive overview of HF in the Americas. Although patient profiles were broadly consistent with global trends, important regional features were observed, including frequent unhealthy lifestyle habits and underuse of key therapies. The high prevalence of HF with reduced left ventricular ejection fraction, together with elevated intensive care unit admission rates and in-hospital death, suggests potential gaps in care and underscores the need to further evaluate HF care delivery across the region. REGISTRATION: URL: clinicaltrials.gov; Unique Identifier: NCT05295641.
Authors: Sebastián Seni‐Molina, Juan Pablo Arango‐Ibanez, Valentina Villegas‐Céspedes, Andrea Valencia‐Orozco, Hoover O. León‐Giraldo, Yudmila Borges, Elizabeth Sellén Sanchén, Mailyn Vilaú Jiménez, Julian Lugo‐Peña, Gustavo Andres Ortega Ramirez, Luis Roberto Lema, Leandro Parrilla, Gerardo Chazzin, Elirub Rojas Gimon, Claudine Judith Coronel Mariño, Pablo Jose Gonzalez Velasquez, Manuel Hipólito Chaple La Hoz, Alfa Kenia Fernandez, Miguel Eduardo Azañedo Velásquez, Clemente Barron Magdaleno, Esteban Zavaleta Monestel, Juan Carlos Henríquez Bonilla, Maximiliano Pereda, Lauren Cooper, Daniel Quesada‐Chaves, Eduardo R. Perna, Víctor Rossel, Mario Speranza, Mark H. Drazner, Walter Alarco, Alexander Romero‐Guerra, Juan Esteban Gómez‐Mesa, Juan Esteban Gómez‐Mesa, Eduardo R. Perna, Víctor Rossel, Daniel Quesada‐Chaves, Mario Speranza, Mark H. Drazner, Walter Alarco, Alexander Romero‐Guerra, Sebastián Seni‐Molina, Beder Gustavo Farez, Cristian Núñez‐Carrizo, Norberto Raúl Bornancini, Elda Lorena Brocal Ocampo, Leandro Parrilla, Daniela García Brasca, Juan Pablo Allende, Ana Virginia Figueroa, Luis Guillermo Muñoz, Juan Pablo Escalante, Eduardo R. Perna, Domingo César Azcona, Alberto A. Fernández, Adrián Lescano, Luis Roberto Lema, José René Romano, Orlando David Fernández‐Flores, Juan Justiniano Encina, Víctor Rossel, Julián Lugo‐Peña, Gustavo Andrés Ortega Ramírez, Erika María Martínez Carreño, Alex Rivera‐Toquica, Sebastián Campbell‐Quintero, Álvaro Mauricio Quintero‐Ossa, Luis E. Echeverría, María Juliana Rodríguez‐González, Andrés Felipe Buitrago Sandoval, Juan Esteban Gómez‐Mesa, Guillermo Trout‐Guardiola, Gustavo Adolfo Moreno Silgado, Carlos Hernán Calderón Franco, Erwin Eladio Silva Cardona, Germán Camilo Giraldo‐González, Juan Alberto Cerón Benavides, Alexis José Bastardo López, Esteban Zavaleta Monestel, Andrés Ulate Retana, Daniel Quesada‐Chaves, Aymé Alberna Cardoso, Tessa Negrín Valdés, Migdalia Cristina Cóbas Pérez, Maité Goberna Rocha, José Carlos Acosta Abad, Sucel Lázara Figueredo Carrazana, José Carlos López Martín, Mailyn Vilaú Jiménez, Annia María Carrero‐Vásquez, Maikel Santos Medina, Sandra Companioni Montero, Yudmila Borges, Elizabeth Sellén Sanchén, Tahimí Chacón Quesada, Yilian Herrera Domínguez, Elién García Sánchez, Raciel Victores Chacón, Harold Segundo Cedeño Macías, Fausto Bernardo Heredia Villacreses, Manuel Hipólito Chaple La Hoz, Jorge Gustavo Castro Daul, Ricardo Mármol Alvear, David Alejandro Puga Bermúdez, Marlon Patricio Aguirre Espinosa, Nadia Sánchez, Leonardo Bermúdez, Freddy Pow‐Chon‐Long, María Eugenia Menjívar‐De Ramos, Silvia Carolina Lazo‐Majano, Lauren Cooper, Elizabeth Ashley Hardin, Milton Lubeck Herrera, Luis Arturo Rodríguez, Mádelyn Raquel Valle‐Ramos, Pablo José González Velásquez, Sergio Roberto Fausto Ovando, Emilio Samael Peralta‐López, Emilio Samael Peralta‐López, Felix Nunura Arrese, Eduardo Heberto Herrera Garza, Jesús Eduardo Sánchez Hernández, José Benito Álvarez Mosquera, Eufracino Sandoval Rodríguez, Amada Álvarez‐Sangabriel, Clemente Barron Magdaleno, Luis Carlos Pérez Plata, Nilda Espinola‐Zavaleta, Pablo Hurtado Nuñez, Gabriel Frago, Claudine Judith Coronel Mariño, Guillermo Oviedo‐Pereira, Javier Galeano Figueredo, Luz Teresa Cabral‐Gueyraud, Miguel A. Quintana, Ida Fabiola Rodríguez‐Caballero, Sergio Gabriel Vergara, María Paniagua, Miguel Eduardo Azañedo Velásquez, Guillermo Alberto Arana Morales, Carlos Demetrio Renato Pacheco Bancayan, Luis Felipe Anhuaman‐Atoche, Paola Gissela Oliver Rengifo, Juan Carlos More Terán, Ruddy Miguel García‐Safadit, Sarah Raquel Marte‐Arias, Alfa Kenia Fernández, Licurgo Jacob Cruz‐Díaz, Kwame van der Hilst, Gabriela Ormaechea‐Gorricho, Maximiliano Pereda, Raquel E González‐Hormostay, Ximena Patricia Madrid Viteri, Luis Díaz Espinoza, Eglee Castillo González, Elirub Rojas Gimon, Maite Alexandra González Fuentes, Antonella A. Ferrer, Gerardo Chazzin, Niurka Pereira Velasco, José Jesús Marval Saud
Institutions: Fundación Valle del Lili, Icesi University, Instituto de Cardiología y Cirugía Cardiovascular, Institute of Cardiology, El Hospital General de Agudos Carlos G. Durand, Fundação Universitária Vida Cristã, Hospital San Juan de Dios, Hospital San Juan de Dios, Hospital San Juan de Dios, Pontificia Universidad Católica del Ecuador, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, North Shore University Hospital, Hospital São Vicente de Paulo, Instituto Nacional del Tórax, University of Chile, The University of Texas Southwestern Medical Center, Saint Thomas Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,810
OpenAlex ID: W7204471069