Work

Design, synthesis, and biological evaluation of novel pyrimidine–sulfonamide derivatives as multi-targeted COX-2/5-LOX/sEH inhibitors with potential antiproliferative properties

Year: 2026

Type: article

Abstract: of 4.30 ± 0.19 µM, demonstrating 1.6-fold lower potency than the reference AUDA but 5-fold greater potency than celecoxib. Compounds 4c, 4g, and 4j showed promising antiproliferative activity, with compound 4c being the most potent against the pancreatic (Panc-1) cancer cell line, and compound 4j the most effective against the breast MCF-7 cancer cell line. Their efficacy against these two cell lines exceeded that of the reference compounds celecoxib, sorafenib, and doxorubicin. Docking analysis of compound 4c showed a good fit within the active sites of both COX-2 and human sEH.

Source: RSC Advances

DOI: 10.1039/d6ra04113b

Authors: Lamya H. Al-Wahaibi, Alshaimaa Abdelmoez, Stefan Bräse, Salah A. Abdel-Aziz, Bahaa G. M. Youssif

Institutions: Princess Nourah bint Abdulrahman University, Assiut University, Karlsruhe Institute of Technology, Al-Azhar University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042