Year: 2026
Type: article
Abstract: The transcription factor c-Myc is frequently upregulated in human cancers through multiple mechanisms, including chromosomal translocation and gene amplification. Since the human TRIB1 gene is located on chromosome 8q24 in close proximity to the MYC oncogene, the MYC and TRIB1 genes may be co-amplified in a large percentage of human cancers. We herein demonstrate molecular crosstalk between TRB1 and c-Myc. Bioinformatic analyses reveal a positive correlation between MYC and TRIB1 expression across multiple cancer types. In prostate cancer cells, the knockdown of c-Myc reduces TRB1 expression. Mechanistically, c-Myc directly binds to the proximal promoter region of the TRIB1 gene and activates its transcription. Conversely, the depletion of TRB1 decreases c-Myc levels and affects the expression of c-Myc target genes. These results indicate that TRB1 contributes to the oncogenic functions of c-Myc and suggest the potential of the TRB1-c-Myc axis as a therapeutic target for cancer treatment.
Institution: Nagoya City University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: がん遺伝子TEADとp53のクロストークを介した新規がん悪性化機構の解明とその治療応用, c-MycによるEMT誘導の時空間的解析と転移を予測する新規バイオマーカーの探索, Development of anticancer drugs based on a new oncogenic mechanism of a novel oncogene candidate molecule TRB1, G5648142151, G6031602451, G6123008414, Development of Novel Cancer Therapeutics via Induction and Regulation of Cellular Senescence by Tribbles Family Molecules, プロテアソーム阻害薬不応答性を誘導するストレス適応の分子機序解明と新規治療法開発, Visualization of in vivo dynamics of epithelial-mesenchymal transition for spatiotemporal understanding of cancer metastasis and development of novel therapeutic strategies
OpenAlex ID: W7204493246