Work

Lessons in conformational signalling: non-catalytic functions of protein kinase C isozymes

Year: 2026

Type: review

Abstract: There is a growing literature describing non-catalytic functions of active protein kinases, reflecting the importance of these properties in the kinase repertoire. Here, we discuss recent work in this area relating to the kinase activity-independent oncogenic action of protein kinase C (PKC) alpha and draw parallels in relation with another PKC family member. We go on to illustrate some of the challenges in unpicking these non-catalytic properties with reference to the wider kinome, illustrating the issue that the wrong loss-of-function mutation may mislead. Finally, we comment on the opportunities these deeper insights bring. This article is part of the discussion meeting issue 'Epidermal growth factor receptor after 40 years'.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2024.0496

Authors: Angus Cameron, Mathias Cobbaut, Veronique Calleja, Neil McDonald, Peter Parker

Institutions: Queen Mary University of London, Barts Cancer Institute, The Francis Crick Institute, King's College London

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid