Langerhans cell histiocytosis (LCH). Case series
Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm characterized by the proliferation of dendritic cells resembling Langerhans cells. Clinical presentations range from isolated osseous lesions to multisystemic disease involving risk organs. To present and analyze clinical cases of LCH, highlighting the role of radiological findings in differential diagnosis and clinical classification. Pediatric patients with cranial and long bone lesions, described. Imaging studies revealed lytic lesions with cortical erosion and soft-tissue infiltration. Definitive diagnosis was achieved through biopsy and immunohistochemistry (CD1a, langerin, S100). Radiology is essential for early detection and diagnostic orientation, although findings are not pathognomonic. The integration of imaging with clinical and pathological data allows differentiation of LCH from other pediatric entities and supports appropriate therapeutic management. LCH remains a diagnostic challenge due to its rarity and diverse manifestations. The dissemination of case reports contributes to expanding medical knowledge and emphasizes the importance of radiology in clinical practice. Keywords: Langerhans cell histiocytosis; radiology; bone lesions.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204529292