Extended Five-Day Versus Standard Three-Day Artemether-Lumefantrine Systematic Review and Meta-analysis
Year: 2026
Type: other
Abstract: A reproducible R workflow for a systematic review and pairwise meta-analysis of randomized controlled trials comparing extended five-day with standard three-day artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria. The repository links multiple reports from the same randomized parent trials, separates contemporary ten-dose treatment intensification from historical same-dose duration-only schedules, and synthesizes PCR-corrected efficacy, uncorrected recurrence, time-to-recurrence, early parasitological response, safety, pharmacokinetic, and molecular outcomes. The workflow includes sparse-event methods, time-to-event meta-analysis, RoB 2 risk-of-bias assessment, GRADE certainty assessment, validation checks, supplementary analyses, and reproducibility metadata.
Institution: Mbale Hospital
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204604160