Work

First case report of dual ‘double-hit’ malignancy in an axillary lymph node: When metastatic breast cancer collides with marginal zone lymphoma

Year: 2026

Type: article

Abstract: Collision tumor is a rare histopathological finding that occurs when two malignancies of different origin meet together in the same tissue. Collison tumor of metastatic breast invasive ductal carcinoma and marginal zone lymphoma is an extremely rare finding. This represents the first case report describing this association. We report a case of 59 years-old female patient who referred to the oncology clinic with an incidentally discovered breast lump associated with diffuse lymphadenopathy. The patient was asymptomatic otherwise. Diagnostic procedures revealed a diagnosis of metastatic invasive ductal carcinoma and marginal zone lymphoma in the same axillary lymph node. She was treated with appropriate surgical and pharmacological intervention. Follow up with imaging revealed complete resolution of the lesion. Collision tumors represent a unique histopathological entity during which more than one malignancy can be diagnosed. It opens the avenues for diagnosing other malignancies while evaluating the disease of interest. This allows for early diagnosis and proper intervention. Early diagnosis of malignancies is one of the most important prognostic factors in patients with neoplastic condition. Collision tumors are key for diagnosing and treating patients with multiple malignancies.

Source: Current Problems in Cancer Case Reports

DOI: 10.1016/j.cpccr.2026.100443

Authors: Mohammed Alra’e, Qossay Hasasneh, Shahad Abu Ahmad, Hanna Qahoush, Marwan Qubaja

Institutions: Hebron University, Augusta Victoria Hospital, Al-Quds University

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030