Work

Clinicopathological spectrum of ovarian tumors with special emphasis on immunoexpression of p53 and Ki-67 in surface epithelial neoplasms

Year: 2026

Type: article

Abstract: Background: Ovarian cancer incidence shows marked geographic variation across India, with nearly six-fold differences in age-adjusted incidence rates within the northeastern states. Limited access to specialized diagnostic and treatment facilities in this region leads to the referral of patients outside the state for cancer management. Aims and Objectives: The aim of the study was to study the clinicopathological characteristics of ovarian tumors in our region and to evaluate the relationship of p53 and Ki-67 immunoexpression in surface epithelial ovarian neoplasms. Materials and Methods: This hospital-based observational study was conducted from March 2023 to February 2024 in the Department of Pathology, a tertiary care hospital in upper Assam in all resected specimen of ovarian lesions suspected for malignancy. Written relevant clinical details, examination findings, and available radiological and laboratory investigations were recorded. Histopathological analysis and immunohistochemistry (IHC) study were done as per standard protocol. Results: In this study of 50 ovarian tumors, the median age at presentation was 38.7±14.2 years, with most cases occurring between 20 and 39 years. Benign tumors predominated (64%), while malignant and borderline tumors accounted for 30% and 6%, respectively. Serous cystadenoma was the most common benign lesion, and high-grade serous carcinoma (HGSC) was the leading malignant subtype. IHC revealed strong p53 expression in HGSC and universal Ki-67 positivity in malignant tumors. A significant correlation (P<0.05) between p53 and Ki-67 expression underscores their combined diagnostic and prognostic utility in differentiating ovarian tumor subtypes. Conclusion: p53 and Ki67 immunoreactivity increase from borderline to malignant tumors, exhibiting their role in prognostication and management of surface epithelial ovarian tumor.

Source: Asian Journal of Medical Sciences

DOI: 10.71152/ajms.v17i9.5430

Authors: Shashank Shekhar, Aparna Dutta, Nivarani Dutta

Institution: Assam Medical College

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200