Clinicians’ perspectives on the utilization, effectiveness, safety, and clinical outcomes of amoxicillin-clavulanic acid in routine clinical practice: A nationwide survey in India
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: The present survey aimed to evaluate clinicians’ perspectives on the utilization, effectiveness, safety, prescribing practices, and clinical outcomes associated with amoxicillin-clavulanic acid in the management of upper respiratory tract infections (URTIs), skin and soft tissue infections (SSTIs), and other common bacterial infections in routine clinical practice. Methods: This nationwide cross-sectional survey was conducted among clinicians across India using a structured questionnaire designed to assess antibiotic prescribing practices, clinical indications, effectiveness, safety, and treatment outcomes associated with amoxicillin-clavulanic acid. The survey explored the prevalence of common bacterial infections, antibiotic selection patterns, dosage calculation practices, culture and sensitivity testing, preferred formulations, treatment duration, management of adverse effects, and patient outcomes. Responses were analyzed descriptively using frequencies and percentages and are presented as such. Results: A total of 439 clinicians participated in the survey. The majority of respondents (73.8%) reported respiratory tract infections (RTIs) as the most frequently encountered condition requiring antibiotic therapy in routine clinical practice. Approximately 95% of clinicians identified amoxicillin–clavulanic acid as the preferred first-line treatment for acute bacterial rhinosinusitis. Nearly two-thirds (65.83%) of respondents reported frequently prescribing amoxicillin-clavulanic acid for the management of SSTIs. More than half (59.68%) of the clinicians considered its broad-spectrum antibacterial coverage, strong bacteriological efficacy, and favorable clinical outcomes to be its key advantages. Regarding medication administration practices, 47% of respondents recommended storing reconstituted amoxicillin-clavulanic acid syrup at room temperature. For the management of antibiotic-associated loose stools, 56% of clinicians advised probiotic supplementation. Nearly 66% of respondents reporting marked clinical improvement on the 5-point Global Improvement Scale. Conclusion: This survey highlights amoxicillin-clavulanic acid as a widely utilized and effective antibiotic for the management of RTIs, SSTIs, and other community-acquired bacterial infections. Clinicians recognize its broad-spectrum antibacterial activity, good tolerability, and favorable clinical outcomes, and continue to express confidence in its role as an important therapeutic option in routine clinical practice.
Authors: Manjula S, Krishna Kumar M
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7204828296