Hepatic protection of resveratrol in mice injected with a virulent strain of Brucella melitensis
Year: 2026
Type: article
Abstract: ABSTRACT Introduction: Resveratrol, a natural polyphenolic compound of the stilbene group, has various biochemical and physiological effects such as anti-inflammatory, antioxidative, anticarcinogenic, antiproliferative, and chemopreventive effects. Brucellosis is the most important zoonosis in several parts of the world. It is still endemic, affecting both the financial and public health sectors. Brucella melitensis species is the most pathogenic, responsible for the abortion of pregnancy in both animals and humans. Methods: The present study was designed to improve liver enzymes by resveratrol against B. melitensis injected in mice. Fifty mice were split equally into five groups: as a control, Group 1 administered 0.3 mL of normal saline orally. Group 2 received a virulent B. melitensis strain (1 × 10 8 ) CFU/mL I/P infection, acting as a control positive. A 10 mg/kg B.W. dose of resveratrol was given to Group 3. Group 4 received resveratrol (10 mg/kg B.W.) treatment after contracting B. melitensis . Group 5 was infected with B. melitensis (1 × 10 8 ) and given resveratrol (10 mg/kg B.W.). Five mice from each group were killed at the halfway point of the trial, on 30 and 60 days. In addition to processing small liver parts for histopathology, blood enzyme tests for alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (GGT) were performed to determine liver enzyme levels. Results: The findings revealed that, in comparison to groups (G1 and G3 with G5), group 2 (G2) had higher liver enzymatic levels at 30 and 60 days, severe pathological consequences in the liver, such as the development of an abscess with hepatic injury, damage, and necrosis thirty days after infection and the occurrence of inflammatory cells, particularly neutrophils, in the micro abscess with pyogranuloma with the infiltration of inflammatory cells, particularly lymphocytes and macrophages. Conclusion: The findings of this study indicate that resveratrol protects mice’s livers from B. melitensis infection by acting as an antioxidant, anti-inflammatory, and anti-cancer agent.
Source: Avicenna
DOI: 10.5339/avi.2026.12
Institution: Middle Technical University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7204880982