Association of Sleeve Gastrectomy With Glycemic Control in Jordanian Adults With Type 2 Diabetes Mellitus and Dysglycemia
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Purpose To evaluate whether sleeve gastrectomy is associated with better glycemic and metabolic outcomes than non-surgical management in Jordanian adults with type 2 diabetes mellitus (T2DM) and dysglycemia. Methods This retrospective cohort study included 239 adults treated at Prince Hamza Hospital in Amman, Jordan: 65 underwent sleeve gastrectomy and 174 received medical management. Baseline and follow-up data included BMI, HbA1c, insulin use, comorbidities, and microvascular complications. The primary outcome was glycemic control, defined as HbA1c < 6.5%. Group comparisons were performed using parametric and non-parametric tests. Modified Poisson regression with robust variance estimation was used to adjust for age, sex, baseline BMI, duration of T2DM and dysglycemia, baseline HbA1c, and insulin use. Results Median follow-up HbA1c was 5.2% after sleeve gastrectomy and 7.5% with medical management (p < 0.001). Among patients with available follow-up HbA1c measurements, glycemic control was achieved in 57 of 59 surgical patients (96.6%) and 42 of 167 medically managed patients (25.1%). Mean BMI changed by − 10.9 kg/m² in the surgery group and + 1.3 kg/m² in the non-surgical group (p < 0.001). New microvascular complications occurred in 4.6% and 16.1% of patients, respectively. After adjustment, sleeve gastrectomy remained independently associated with glycemic control (adjusted risk ratio 4.92, 95% CI 2.37–10.24; p < 0.001). Conclusion Sleeve gastrectomy was associated with better glycemic control and greater BMI reduction than non-surgical management in this Jordanian cohort. A lower frequency of newly documented microvascular complications was also observed in the surgical group, although this exploratory finding should be interpreted cautiously.
Source: Research Square
Institution: Hashemite University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204885765