Histoprotective Effect of Aqueous Extract of Cardamom against Cadmium Chloride Induced Toxic Effect in Mice
Year: 2026
Type: article
Abstract: Introduction: Elettaria cardamom [EC], recognized as "queen of spices", relates the ginger family, Zingiberaceae. Seeds contains many plant chemicals substance like starch, phenols, terpinoids, flavonoids, tannins, proteins and sterols. These contents have been used to treat many infections in the mouth like gums, throat, teeth and also treat lung disease such as tuberculosis, pulmonary congestion, hypertension, heart disease and digestive system disorders. The anticancer benefits of cardamom are attributed to its identified mechanisms, which include anti-proliferative, anti-inflammatory, pro-apoptotic, and antioxidant actions. Methods: In this study, 15 male mice were obtained from animal house at the Pharmaceutical Research and Control Center weighing between 30-45 g. The animals were divided in to 3 groups, 5 mice in each group. Group 1: was administered with 2.5 mg/kg of CdCl2 with normal saline orally as control croup. Group 2: was administered with 2.5 mg/kg of CdCl2 and cardamom [200 mg/kg]. Group 3: was administered with 2.5 mg/kg of CdCl2 with cardamom [300 mg/kg] for six weeks. Results: The results showed the protective effect of cardamom against histological damage caused by substances like cadmium chloride and increase recovery of the histological characters in groups treated cardamom 200 and 300 mg/kg. The group treated 300 mg/kg cardamom showed better results than with 200 mg/kg. KEYWORDS: Elettaria cardamom, Cadmium Chloride, Histological damage, antioxidant, cardamom, histoprotective.
Institutions: Middle Technical University, University of Kerbala
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7204890613