Results of an in vitro experimental study of a new intrastromal keratoprosthesis support plate
Year: 2026
Type: article
Abstract: Purpose. To study the cellular and tissue response to intrastromal fixation of a new keratoprosthesis support plate in the human cadaveric cornea in comparison with the Fedorov — Zuev keratoprosthesis support plate using the organotypic cultivation method. Material and methods. In this work, a series of experimental and morphological studies was conducted, including an in vitro experiment that involved immunohistochemical and histological examinations, as well as electron scanning microscopy, in which two experimental groups were compared: Group 1 (n=5) — corneas with an implanted intrastromal model of a supporting plate made of a biocompatible spatially cross-linked acrylic polymer based on oligomers and monomers of the methacrylic series with a uv-filter; Group 2 (n=5) — corneas with an implanted supporting plate of the Fedorov — Zuev keratoprosthesis. Results. In the course of a series of experimental studies, the bioinertness of the studied intrastromal supporting plate made of hydrophobic acrylic was confirmed, and the material’s biocompatibility and high integrative capabilities were proven, in contrast to the support plate of the Fedorov — Zuev keratoprosthesis. Conclusion. The development of a new synthetic support plate model with an optimal size and design is one of the current areas of keratoprosthetics. A pilot study demonstrated the effectiveness, biocompatibility and safety of the developed intrastromal keratoprosthesis support plate compared to the existing Fedorov — Zuev keratoprosthesis support plate. Keywords: keratoprosthesis, organotypic culture, scanning electron microscopy, immunohistochemistry, light microscopy
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7204990267