Work

The Role of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker in Predicting the Function of Kidney Grafts: A Literature Review

Year: 2026

Type: review

Abstract: Background/Objectives: Kidney transplantation is the gold standard treatment for end-stage renal failure. Numerous studies have sought to identify biomarkers that can predict early outcomes. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker that is hypothesised to be an important predictor of early surgical outcomes. Methods: A targeted narrative search was performed using prespecified search terms. Reference lists were searched to identify and yield more articles. Discussion: This review has identified several domains in which urinary and serum NGAL may be useful as well as limitations in its application. Conclusions: NGAL is a promising biomarker; however, further research is necessary to establish best practice in its use in the early post-operative phase.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm15176803

Authors: Alexander A. Dermanis, Dominic Thompson, Georgios Koimtzis

Institutions: Glangwili General Hospital, University Hospital of Wales

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137