Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study
Year: 2026
Type: article
Study design: Observational Study
Abstract: PURPOSE: We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. METHODS: This retrospective, multicentre observational study included oligometastatic patients with primary solid tumours treated with SBRT between 2020 and 2024 across 12 Spanish radiotherapy centres. The primary endpoint was 1-year progression-free survival (PFS). The secondary endpoints included overall survival (OS), local control (LC), and acute and late adverse events by CTCAE v.5.0. RESULTS: 300 patients with 451 treated lesions were included. Median age was 69 years. After a median follow-up of 22 months, 1- and 2-year PFS were 45.1% and 36.3% respectively, with a median PFS of 11 months (95% CI, 9-13). The 1- and 2-year OS were 92% and 82.9% (median not reached), and 1- and 2-year LC were 90.5% and 85.5% respectively. Multivariable analyses showed significantly better PFS and OS in prostate cancer patients. Repeat and induced oligometastatic patients showed worse PFS than those with synchronous disease (HR 2.86, 95% CI 1.59-5.13; p<0.001 and HR 2.97, 95% CI 1.58-5.57; p<0.001, respectively). Visceral-only disease also correlated with worse PFS compared to bone-only metastases. Local control was poorer in lesions ≥5 cm compared to <5 cm (p<0.001). Grade ≥3 acute and late adverse events occurred in 0.7% and 1% of patients. CONCLUSION: In this real-world multicentre cohort, SBRT to the oligometastases showed efficacy with minimal adverse events. Prognostic differences among subgroups underscore the importance of an adequate patient selection and individualized treatment strategies.
Authors: Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago
Institutions: Hospital General Universitario Gregorio Marañón, Universidad Autónoma de Madrid, Hospital Universitario Ramón y Cajal, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Universidad Europea de Madrid, IDCQ Hospitales y Sanidad, S.L.U., GenesisCare, Hospital Universitario de Torrejón, Hospital Universitari i Politècnic La Fe, Universidad Rey Juan Carlos, Hospital Universitario Rey Juan Carlos, The University of Melbourne, Peter MacCallum Cancer Centre, University of Freiburg, European University Cyprus, University Medical Center Freiburg
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,690
Funder: Universidad Autónoma de Madrid
OpenAlex ID: W7204995867