Exploring novel molecularly-targeted therapies which modulate anti-apoptotic proteins in endometrial and ovarian cancers
Year: 2018
Type: dissertation
Abstract: Apoptosis, or programmed cell death, is a genetically-controlled process in which a cell undergoes self-destruction.It is characterized by definite morphological features which include cell shrinkage, blebbing of the membrane, condensation of the nucleus and DNA fragmentation.Apoptosis can be triggered by both intrinsic and extrinsic stimuli under both physiological and pathological conditions.Several anti-and pro-apoptotic proteins are involved in the control of this vital process.In most cancers, however, apoptosis is either aberrant or lacking which leads to the accumulation of cells with faulty DNA and altered cellular processes, consequently, resulting in relentless cellular proliferation.Circumventing apoptosis is a hallmark of most malignant tumors.
DOI: 10.15083/00078336
Author: Chuwa, Agapiti Hipoliti
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7207540139