Type: report
Abstract: and mRNA degradation regulated by RNA binding protein in response to cell signals研究成果の概要(英文)：We show that ZFP36L1 represses translation initiation, and demonstrate that this effect is independent of deadenylation mediated by the ARE.Strikingly, ZFP36L1-mediated translation repression nevertheless requires interaction between ZFP36L1 and CNOT1.Moreover, the eIF4F complex remains bound to the mRNA even in the presence of ZFP36L1.These observations imply that ZFP36L1-mediated repression of translation initiation differs fundamentally from the mechanism used by miRISC.Moreover, we find that translational repression by ZFP36L1 is also independent of 4EHP, despite this being a key factor for translation repression by ZFP36L.Collectively, our results highlight surprising diversity of regulatory mechanisms used by ARE-BPs and factors that interact with the CCR4/NOT co-factor complex.
Language: Japanese
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7207968680