Five Cases of Palliative Whole-liver Irradiation in a Single Fraction for Multiple Liver Metastases
Year: 2026
Type: article
Study design: Case Report
Abstract: Purpose : To report on single-fraction palliative whole-liver irradiation for multiple liver metastases at our institution. Methods : We retrospectively reviewed five patients who underwent single-fraction palliative whole-liver irradiation for multiple liver metastases at our hospital between August 2023 and September 2024. Patient characteristics, radiotherapy details, treatment efficacy, and adverse events were evaluated. Results : The patients ranged in age from 28 to 76 years (median, 58). Primary malignancies included gastric neuroendocrine carcinoma (n＝2), lung adenocarcinoma (n＝1), uterine sarcoma (n＝1), and cutaneous malignant melanoma (n＝1). According to the Child-Pugh classification, three patients were class A and two were class B. All patients had symptoms attributable to multiple liver metastases, and abdominal pain was present in four of the five patients. Radiotherapy was delivered using three-dimensional conformal radiotherapy in all cases, with a prescribed dose of 8 Gy in a single fraction. Four patients received premedication to prevent radiation-induced nausea. The follow-up period ranged from 0.7 to 5.6 months (median, 2.5). Symptomatic improvement was observed in three of the five patients, and abdominal pain improved in two of the four patients who initially had abdominal pain. No severe adverse events were observed. Conclusion : Single-fraction palliative whole-liver irradiation showed a certain degree of effectiveness at our institution. Shinshu Med J 74 : 169 ―173, 2026
Authors: 杉村, 美優, 小岩井, 慶一郎, 20419360, KOIWAI, Keiichiro, 長田, 景也, 酒井, 阿裕美, SAKAI, Ayumi, 神事, 優香, JINJI, Yuuka, 遠藤, 優希, ENDO, Yuuki, 藤永, 康成, 70334901
Institution: Shinshu University
Language: Japanese
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7208047419