Base‐Free Nickel‐Catalyzed Three‐Component Coupling of Aldehydes, Butadiene, and Malonate Derivatives: Toward Sustainable Synthesis of Highly Functionalized Molecules
Year: 2026
Type: article
Abstract: We report a nickel‐catalyzed multicomponent reaction between benzaldehyde derivatives, butadiene, and various malonates under mild conditions. The protocol provides a straightforward one‐step synthesis of homoallylic alcohols functionalized with a double bond and a malonate moiety without the need for any additional base or cocatalyst. The synthesis is highly selective yielding a single E ‐isomer.
DOI: 10.1002/ejoc.70819
Institutions: Centre National de la Recherche Scientifique, Université de Lille, Unité de Catalyse et Chimie du Solide, Centrale Lille Institut, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie, Université de Caen Normandie, Miniaturisation pour la Synthèse, l'Analyse et la Protéomique
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,330
OpenAlex ID: W7208737019