Biomarkers of Oral Squamous Cell Carcinoma: Potential Diagnostic and Prognostic Tools
Year: 2025
Type: article
Abstract: Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor characterized by high morbidity and mortality. Early diagnosis and accurate prognostic evaluation are vital for improving patient outcomes. Objective: This review aims to explore recent developments in the study of biomarkers related to OSCC and assess their potential value in diagnosis, treatment evaluation, and prognosis. Methods: A comprehensive analysis of current literature was conducted, focusing on various categories of biomarkers—including genes, proteins, and non-coding RNAs—and their biological roles and clinical applications in OSCC. Results: Recent studies have identified multiple biomarkers with diagnostic and prognostic significance. Genetic biomarkers (such as TP53, NOTCH1, and P16INK4a), protein biomarkers (including SOX family, HIF-1α, and E-cadherin), and non-coding RNAs (notably MALAT1) have demonstrated potential for early detection, therapeutic monitoring, and prognosis prediction in OSCC patients. Conclusion: The integration of genetic, protein, and RNA biomarkers represents a promising approach to improving early diagnosis, treatment assessment, and individualized care for OSCC. Continuous research and clinical validation are necessary to enhance their applicability in future medical practice.
Authors: Wei Lian Deng, Liu Lin, Zou Yu Ting
Institutions: Mahsa University, Youjiang Medical College for Nationalities
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7208765216