Formulation and Evaluation of Mucoadhesive Herbal Oral Gel Containing Scutellaria Baicalensis Extract for the Treatment of Oral Inflammatory Conditions
Year: 2026
Type: article
Abstract: The present study aimed to formulate and evaluate a mucoadhesive herbal oral gel containing Scutellaria baicalensis extract for the treatment of oral inflammatory conditions. The plant extract, rich in flavonoids such as baicalin and baicalein, exhibits significant anti-inflammatory, antimicrobial, and antioxidant properties. Herbal gel formulations (F1-F6) were prepared using Carbopol 940 as a gelling agent with varying concentrations to optimise physicochemical and release characteristics. The formulations were evaluated for pH, viscosity, spreadability, drug content, in-vitro diffusion, antimicrobial activity, anti-inflammatory activity, and mucoadhesive strength. Results indicated that all formulations showed acceptable physicochemical properties. Among them, formulation F4 demonstrated an optimal balance of viscosity, spreadability, and sustained drug release. In-vitro diffusion studies revealed controlled drug release following Higuchi kinetics, indicating a diffusion-controlled mechanism. The formulation also exhibited significant antibacterial activity against E. coli and notable anti-inflammatory activity. The developed herbal gel showed promising potential as an effective localised drug delivery system for oral conditions.
Institution: People’s University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7208814014