Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Intracranial meningiomas are the most common primary brain tumors in adults, with a female predominance suggesting hormonal influence. Progesterone receptor (PR) expression inversely correlates with tumor grade, but data from Bangladesh are limited. Objective: To assess the clinicopathological profile, tumor characteristics, and association of PR status with histopathological grading in intracranial meningioma. Methods: This cross-sectional study was conducted at Bangabandhu Sheikh Mujib Medical University, Dhaka, from June 2018 to March 2020. Thirty-eight patients with histologically confirmed intracranial meningioma were enrolled. Tumor location and size were assessed on MRI. Histopathological grading followed WHO 2021 classification. PR status was determined by immunohistochemistry (positivity ≥10% nuclear staining). Statistical analysis used SPSS version 26, with p<0.05 considered significant. Results: Mean age was 55.2±12.8 years; 63.2% were female (F: M 1.7:1). Headache (68.4%) was the commonest symptom. Convexity was the most frequent location (39.5%); mean tumor diameter was 4.3±1.5 cm. WHO grading showed 78.9% grade I, 18.4% grade II, and 2.6% grade III. Overall PR positivity was 68.4%. PR expression was highest in grade I (80.0%), decreasing in grade II (28.6%), and absent in grade III (0%), showing significant inverse association (p=0.021). Strong PR expression (>60%) occurred only in grade I tumors (26.7%). Conclusion: PR expression is significantly associated with lower histological grade in intracranial meningiomas, supporting its role as a favorable prognostic marker. PR immunohistochemistry is a valuable, cost-effective adjunct to routine histopathological evaluation.
Source: ARC Journal of Neuroscience
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7208828550