Data Repository for "C-terminal evolutionary remodelling of isoleucyl-tRNA synthetases is a prokaryote-specific strategy for tuning aminoacylation rate"
Year: 2026
Type: dataset
Abstract: This repository contains the bioinformatic data associated with the paper "C-terminal evolutionary remodelling of isoleucyl-tRNA synthetases is a prokaryote-specific strategy for tuning aminoacylation rate" by Modrusan, Brkic, Lecona Buttelli, Leibundgut, Zivkovic, Ban, Longo, and Gruic-Sovulj. It includes: A curated set of 97,680 full-length IleRS protein sequences, together with per-sequence HMM domain annotations (coordinates, e-values, coverage), domain architectures, predicted IleRS class, and GTDB/EukProt identifier. HMM profiles used for sequence retrieval, the archaeal, bacterial, and eukaryotic sequence sets recovered from GTDB and EukProt, and the Sequence Similarity Networks (SSNs) used to filter candidate IleRS sequences. Domain-level maximum-likelihood phylogenetic trees (HUP, ARD1, CP1, CP2, and ED domains), including the underlying sequence sets and alignments used to build them. A frozen copy of DOTATE (v1.2.0), the code used to generate the HMM domain annotations from HMMsearch output Full details on how each file was generated are provided in the Methods section of the associated paper. Please cite the paper above if you use this data.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7212157752