Analysis code for: Phenotype-dependent coupling of tau and neurodegeneration along a disease-time axis in Alzheimer's disease
Year: 2026
Type: software
Abstract: Analysis code and the Stan disease-time (latent-time) model for the study "Phenotype-dependent coupling of tau and neurodegeneration along a disease-time axis in Alzheimer's disease." Includes disease-time estimation (Stan/CmdStanR), vertex-wise feature extraction (mixed-effects BLUPs), non-negative matrix factorization, tau–neurodegeneration coupling analyses, sensitivity analyses, and table generation. No participant data are included; source data are available from ADNI, OASIS-3, and HABS-HD under their respective data-access procedures. Image preprocessing (standard CAT26, SPM-based pipeline) and figure-rendering scripts are available from the corresponding author on request. See README.md for the pipeline map and per-script index.
Authors: Fujishima, Motonobu, Kawaguchi, Atsushi
Institutions: Kumagaya General Hospital, Saga University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7212367388