Work

Pharmacological agents for promoting diabetic wound healing

Year: 2026

Type: review

Abstract: Diabetic wounds are highly susceptible to chronicity and infection due to impaired healing involving multiple pathophysiological factors. Despite extensive preclinical and clinical research, few approved drugs have been shown to effectively accelerate diabetic wound healing. This review highlights pharmacological interventions for diabetic wound healing, summarizes the current status of drug development, and discusses their potential mechanisms of action. These agents include inflammation-modulating agents, pro-proliferative agents, remodeling-regulating agents, hypoxia- and microcirculation-targeting agents, antioxidant agents, and multi-target agents, such as bioactive constituents from plants and traditional Chinese medicine (TCM) formulas. This review aims to guide future drug development strategies for diabetic wound healing.

Source: Acta Pharmaceutica Sinica B

DOI: 10.1016/j.apsb.2026.09.007