Work

Association Between High-Density Lipoprotein Cholesterol Efflux Capacity and Renal Function in Patients With Type 2 Diabetes

Year: 2026

Type: article

Abstract: Background: The cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) (HDL-CEC) is inversely associated with atherosclerotic cardiovascular disease. Type 2 diabetes mellitus (T2DM) is frequently complicated by chronic kidney disease (CKD), usually associated with increased homocysteine (Hcy), and these conditions are likely to be involved in HDL dysfunction. However, the relationship between HDL-CEC and CKD, as well as Hcy levels in patients with T2DM remains unclear. Methods and Results: This cross-sectional study involved 138 patients with T2DM. CEC was measured using a stable-isotope method with J774 macrophage-like cells and apolipoprotein B-depleted serum. Multiple regression analysis showed that sex (β=0.278; P=0.005), estimated glomerular filtration rate (eGFR; β=0.232; P=0.038), and HDL cholesterol (HDL-C; β=0.197; P=0.030) were independently associated with CEC. Conclusions: Sex, eGFR, and HDL-C were independently associated with HDL-CEC in patients with T2DM. These findings suggest that impaired renal function may be related to impaired HDL function in this population, although causal relationships cannot be inferred from this cross-sectional analysis.

Source: Circulation Reports

DOI: 10.1253/circrep.cr-26-0219

Authors: Takahiro Hadano, Sadako Matsui, Chika Hiraishi, Kei Fujimoto, Keiichiro Matoba, Hiroshi Yoshida