Work

EP608 - ECE_3077 - Phosphocalcic profile and risk of calcium nephrolithiasis in patients with metabolic syndrome

Year: 2026

Type: conference-abstract

Abstract: Background Metabolic syndrome (MetS) is a major public health concern due to its high prevalence and associated complications. Beyond well-known metabolic and cardiovascular consequences, MetS has increasingly been linked to renal involvement, particularly urinary stone formation. Identifying early urinary risk factors in patients with MetS may help prevent future stone formation. Methods A descriptive cross-sectional study was conducted over a 13-month period in adult patients followed for metabolic syndrome according to the NCEP-ATP III criteria at the Endocrinology-Diabetology Department of Hedi Chaker University Hospital, Sfax.Clinical, nutritional, biochemical, and 24-hour urinary parameters were collected. Univariate and multivariate logistic regression analyses were performed to identify factors associated with lithogenic abnormalities. Results A total of 85 patients were included, median age was 54.04 ± 0.88 years , a female predominance was noticed (male-to-female ratio: 0.25),median body mass index (BMI) was 37.4 kg/m²; 82.4% of patients were obese and 64.7% had morbid obesity. Thirty-three patients (38.8%) met three MetS criteria, while 23.5% met all five criteria. Biochemically, hypo-HDL cholesterolemia was present in 51.8%, hypertriglyceridemia in 36.5%, and dysglycemia in 77.6%. Vitamin D deficiency was observed in 88.2% of patients. The median urinary pH was 5.45 . Lithogenic urinary abnormalities included hyperuricosuria (36.5%), hypomagnesuria (34.1%), hyperphosphaturia (28.2%), hypercalciuria (16.5%), and hyperoxaluria (2.4%). Crystalluria was detected in 17.6% of cases. Univariate analysis of predictors of lithogenic risk associated with hypercalciuria showed that, in terms of social factors, patients with hypercalciuria had significantly lower age compared with those without hypercalciuria (P = .01). Concerning clinical factors, hypercalciuria was significantly more frequent in patients with higher BMI, morbid obesity, and excessive salt intake (P = .001 for each). Biological parameters showed no significant association between hypercalciuria and serum lipids profile, or fasting glucose levels. In multivariate analysis, BMI and excessive salt intake were independently associated with hypercalciuria, with adjusted odds ratios of 1.13 (95% CI: 1.03-1.24) and 14.8 (95% CI: 2.96-74.52), respectively. No significant association was found between the number of metabolic syndrome components and lithogenic factors; however, a non-significant increase in urinary oxalate (P = 0.07) were observed as the number of metabolic syndrome criteria increased. Conclusions Metabolic syndrome is a recognized risk factor for calcium nephrolithiasis, underscoring the need for targeted preventive measures. Systematic metabolic assessment and lifestyle interventions are recommended, with intensified evaluation and annual follow-up for patients with risk factors as Obesity and high sodium intake or biochemical abnormalities

Source: European Journal of Endocrinology

DOI: 10.1093/ejendo/lvag096.1049