Work

Figure 1 from CRB-701: A Second-generation Nectin-4–Targeted Antibody–Drug Conjugate with Optimized Stability and Pharmacokinetics for the Treatment of Solid Tumors

Year: 2026

Type: other

Abstract: Structure of CRB-701. CRB-701 is comprised of a novel anti-human nectin-4 mAb conjugated to a molecule of LND1002 at the Q294 position of each heavy chain, yielding a mean DAR of 2. Each LND1002 molecule comprises a PEG moiety, a valine-citrulline p-aminobenzyl carbamate cathepsin B cleavable linker, and MMAE.

DOI: 10.1158/2767-9764.33790217

Authors: Zhaopeng Sun, Mo Dan, Lu Lv, Mingyue Shen, Can Yuan, Congcong Niu, Yang Zhang, Xixin Hu, Xiwu Hui, Andrew Kolodziej

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7213312901

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