Early outcomes after venous thromboembolism in Hispanic and non-Hispanic patients: insights from the Registro Informatizado de Enfermedad TromboEmbólica Registry
Year: 2026
Type: article
Abstract: Background: Racial and ethnic differences in venous thromboembolism (VTE) incidence have been reported, but Hispanic patients remain underrepresented in VTE cohorts, and their 90-day postdiagnosis outcomes remain incompletely characterized. Objectives: To compare 90-day risks of recurrent VTE, major bleeding, and mortality between Hispanic and non-Hispanic patients with acute VTE. Methods: Exposure-matched analysis of the Registro Informatizado de Enfermedad TromboEmbólica Investigators registry, a prospective, international cohort of adults with acute VTE. Hispanic patients were matched 1:3 to non-Hispanic patients by age, sex, index VTE phenotype, active cancer, and calendar period. The matched cohort included 1792 Hispanic and 5376 non-Hispanic patients. Exposure was self-identified Hispanic ethnicity. Main outcomes and measures were 90-day recurrent VTE, major bleeding, and all-cause mortality. Odds ratios (ORs) with 95% CIs were estimated using hierarchical logistic regression. Results: The matched cohort had a mean age of 57 ± 18 years, and 59% were women. At 90 days, recurrent VTE occurred in 1.6% of Hispanic patients and 1.2% of non-Hispanic patients (absolute difference, 0.4 percentage points); major bleeding occurred in 2.1% and 1.7%, respectively (absolute difference, 0.4 percentage points); the composite outcome occurred in 3.4% and 2.9%, respectively (absolute difference, 0.5 percentage points); and mortality occurred in 4.1% and 3.9%, respectively (absolute difference, 0.2 percentage points). In fully adjusted models, Hispanic ethnicity was associated with increased odds of recurrent VTE (OR, 1.90; 95% CI, 1.10-3.28), major bleeding (OR, 1.73; 95% CI, 1.09-2.75), and the composite outcome (OR, 1.77; 95% CI, 1.23-2.54), but not mortality (OR, 1.05; 95% CI, 0.68-1.64). Conclusion: In this matched registry analysis, self-identified Hispanic ethnicity was associated with modestly higher adjusted odds of recurrent VTE and major bleeding, but not mortality. Although adjusted relative estimates differed, absolute differences were small. These observational associations should not be interpreted as causal because residual confounding cannot be excluded.
Authors: Lizbeth Cabrera, Alfonso Tafur, Leticia Guirado-Torrecillas, Jose Maria Pedrajas, Fares Moustafa, Concepción Falgá, Aída Gil-Díaz, Andris Skride, Javier Pagán Escribano, Manuel Monreal, Manuel Monreal, Paolo Prandoni, Benjamin Brenner, Dominique Farge-Bancel, Raquel Barba, Peter Verhamme, Hugo Hyung Bok Yoo, Radovan Malý, Laurent Bertoletti, Sebastian Schellong, Inna Tzoran, Pierpaolo Di Micco, Abilio Reis, Marijan Bosevski, Lucia Mazzolai, Joseph A. Caprini, My Hanh Bui, A. Abad-Fernández, L. Afonso-Nuez, P. Agudo, J. Aibar, A. Alberich-Conesa, J. Álvarez-Albarrán, C. Amado, M. Angelina-García, J.I. Arcelus, A. Ballaz, R. Barba, M. Barrón, B. Barrón-Andrés, J. Bascuñana, F. Beddar-Chaib, Á. Blanco-Molina, I. Cabello-Rojano, N. Chamorro, L. Chasco, G. Claver, J. Creu-Paris, Criado J, Juana-Izquierdo C. De, J. Del Toro, P. Demelo-Rodríguez, J.D. Díaz-Anichiarico, M.C. Díaz-Pedroche, J.A. Díaz-Peromingo, D. Durán, P. Esquerdo-Serrano, C. Falgá, C. Fernández-Martínez de Septién, J. Ferreiro-Celeiro, Á. Fidalgo, A. Formica, I. Francisco, C. Gabara, F. Galeano-Valle, F. García-Bragado, A. García-Ortega, O. Gavín-Sebastián, A. Gil-Díaz, E. Girona, C. Gómez-Cuervo, J. González-Olmedo, I. Gorostidi-Álvarez, J. Gorostidi-Pérez, L. Guirado, J. Gutiérrez-Guisado, L. Hernández-Blasco, J. Hernández-Borge, D. Jiménez, R. Jiménez, I. Jou, M.D. Joya, A. Larrauri, P. Llamas, P. López-Miguel, J.J. López-Núñez, A. López-Ruiz, J.B. López-Sáez, A. Lorenzo, P. Lucas-García, O. Madridano, P.J. Marchena, M. Martín-del Pozo, M. Monreal, L. Monzón-Escribano, A. Moreno-Fernández, J.A. Nieto, M.J. Núñez-Fernández, M. Olid, L. Ordieres-Ortega, M. Ortiz, S. Otálora, J. Pagán, P. Parra-Caballero, J.M. Pedrajas, M. Pérez-Pinar, C. Pérez-Ductor, M.L. Peris, M.L. Pesce, G. Puche, A. Rodríguez-Cobo, M.D. Rojas-Piñero, P. Ruiz-Artacho, N. Ruiz-Giménez, M. Sánchez-Camacho, T. Sancho, V. Sendín, T. Sidawi-Urbano, G. Sierra-Palomares, P. Sigüenza, L. Sindín-Martín, A. Solé, L. Teres-Pueyo, M.R. Toda, J. Trujillo-Santos, L. Tudela, R. Valle, J.F. Varona, E. Vega-Romero, P. Villares, C. Ay, S. Nopp, I. Pabinger, M. Erard, Q. Van Thillo, P. Verhamme, H.H.B. Yoo, S.E. Carbonell, J.E. Gómez-Mesa, A.C. Montenegro, J. Roa, P. Grenar, J. Hirmerova, R. Malý, S. Accassat, S. Benarroch, L. Bertoletti, A. Bura-Riviere, J. Catella, R. Chopard, R. Duong, O. Espitia, B. Leclercq, I. Mahé, G. Millet, F. Moustafa, G. Poenou, G. Sarlon-Bartoli, S. Schellong, Y. Jenab, A. Khodayari, P. Sadeghipour, S. Yadangi, B. Brenner, N. Dally, I. Tzoran, G. Barillari, F. Bilora, C. Bortoluzzi, M. Bortoluzzi, B. Brandolin, G. Buso, M.M. Ciammaichella, P. Di Micco, A. Guida, E. Imbalzano, A. Licci, C. Marcon, D. Mastroiacovo, U. Mazzarelli, R. Pesavento, V. Pizzuti, A. Poz, P. Prandoni, M. Provisione, P. Scarinzi, A. Visonà, N. Vo Hong, B. Zalunardo, H. Cesnieks, A. Skride, M. Zicans, S. Fonseca, M.D. Martins, C. Pereira-Fontes, M. Bosevski, M. Boshevska, S. Barco, L. Mazzolai, D.J. Angiolillo, B. Bikdeli, J.A. Caprini, L. Ortega-Paz, A.J. Tafur, M.H. Bui, S.T. Nguyen, G.B. Tran
Institutions: University of Chicago, Endeavor Health, Hospital Universitario Virgen de la Arrixaca, Hospital Clínico San Carlos, Centre Hospitalier Universitaire de Clermont-Ferrand, Hospital de Mataró, Hospital Universitario de Gran Canaria Doctor Negrín, Riga Stradiņš University, Hospital General Universitario Morales Meseguer, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Universidad Católica de Murcia
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,250
OpenAlex ID: W7213354529