Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): A mixed-methods, multi-centre feasibility randomised controlled trial
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background Cognitive difficulties are common in people with multiple sclerosis (pwMS), yet access to neuropsychological rehabilitation is often limited or only provided to those with more severe impairments. The NEuRoMS intervention provides brief, tailored neuropsychological rehabilitation for pwMS with mild-to-moderate cognitive difficulties. Objectives To evaluate feasibility and acceptability of the intervention and test procedures for a definitive trial. Methods A mixed-methods, multi-centre feasibility randomised controlled trial (RCT) was conducted. Feasibility outcomes were recruitment, retention, outcome completion, randomisation, intervention delivery and fidelity. Quantitative data were collected at baseline, 3- and 6-months, supplemented by interviews with pwMS and healthcare providers. Results Seventy-nine participants were randomised (mean age = 54.5 ( SD = 11.5); 70% women) from three UK MS clinics. Most feasibility criteria were met: retention (>80%) and outcome-measure completion (81%–89%) were high, and trial procedures were acceptable. Intervention delivery was feasible and delivered as intended, but staffing-related recruitment challenges need addressing in future trials. Preliminary signal of efficacy was observed, with 3.42-point difference (effect size = 0.48) in the planned primary outcome (MS psychological impact) favouring the intervention, supported by qualitative evidence of sustained behaviour change. Conclusion The NEuRoMS intervention and trial procedures were feasible and acceptable, with early indication of efficacy. A definitive RCT is underway. Trial registration: ISRCTN11203922; https://doi.org/10.1186/ISRCTN11203922
Authors: Roshan das Nair, Gogem Topcu, Nia Goulden, Shaun Harris, Jacqueline R Mhizha-Murira, Haley Morris, Polly Swain, Lauren A Taylor, Jonathan Hancock, Laura Price, Jenna Hill, Avril Drummond, Zoë Hoare, Deborah Fitzsimmons, Denise Kendrick, Stephen Timmons, Shirley Thomas, Jennifer Martin, Rod Middleton, James C Turton, Clare Bale, Andrea Stennett, Rachel Simkiss, Kimberley Fletcher, Emma C Tallantyre, Klaus Schmierer, Nikos Evangelou, On behalf of the NEuRoMS Collective
Institutions: University of Nottingham, SINTEF, St Olav's University Hospital, Bangor University, Swansea University, University of Birmingham, Nottingham University Hospitals NHS Trust, University of Staffordshire, Queen's Medical Centre, Barts Health NHS Trust, University Hospital of Wales, Cwm Taf University Health Board, Loughborough University, Institute of Mental Health, NIHR MindTech MedTech Co-operative, Queen Mary University of London, Cardiff University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,650
OpenAlex ID: W7213486264