Immunomodulatory Effects of Multi-Component Dietary Supplementation on Humoral and Cellular Immune Responses: A Randomized Controlled Trial
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Multi-component dietary supplements targeting immune function represent a growing clinical intervention strategy. This randomized, double-blind, placebo-controlled trial evaluated the immunomodulatory effects of IMMUN-5 — a capsule-based supplement containing tissue hydrolysate(1mg), ascorbic acid (25 mg), and menthol (5 mg) —in 120 adults withimmunodeficiency-associated conditions over 60 days. Participantsreceived IMMUN-5 (two capsules twice daily) or identical placebo. Outcomes included serum IgG, IgM, and IgA concentrations, CD3+/CD4+/CD8+ T-lymphocyte percentages, NK cell frequencyandcytotoxicity, and phagocytic index, assessed at baseline, Week 4, andWeek8. The IMMUN-5 group demonstrated significantly greater increases inIgG (+34.7%), IgM (+41.1%), CD3+ T cells (+17.6%), NKcytotoxicity(+42.4%), and phagocytic index (+44.4%) compared with placebo(all p<0.001). The CD4+/CD8+ ratio remained stable. Adverse events weremild and comparable between groups. IMMUN-5 significantly enhancedboth humoral and cellular immune parameters without evidence of immunological dysregulation.
Institutions: Tashkent State Medical University, Alfraganus University
Language: English
Topic: Nutrition and Health Studies
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7213971817