Work

Convergence of 3D bioprinting and nanomedicine for advanced lung cancer modeling and targeted therapy

Year: 2026

Type: article

Abstract: ABSTRACT Introduction Lung cancer is one of the major causes of cancer-related deaths around the world, and the late diagnosis and poor therapeutic outcome are still significant clinical problems. Traditional therapies with chemotherapy and radiotherapy have limitations due to systemic toxicity, drug resistance, and lack of tumour specificity. Methods A systematic literature search and data compilation was performed for relevance to the convergence of 3D bioprinting and nanomedicine in lung cancer; the detailed search strategy and eligibility criteria are described using recent publications. Different Nano vesicular systems were identified. The targeting strategies were also discussed. The major focus is on amalgamation of two innovative technologies. Findings 3D bioprinting of lung cancer cells, biomaterials, and extracellular matrix allows accurate spatial control of these components, which closely mimics the native tumour microenvironment. Nanomaterials such as polymeric nanoparticles, liposomes, and metallic nanoparticles enhance drug solubility, stability, and tumour-targeted therapy. Inhalable nanocarrier systems increase concentrations of drugs in the lungs locally and reduce systemic toxicity. Discussion Organized around the framework of tumour-microenvironment features, bioprinted model design, nanomedicine testing, therapeutic readouts, and clinical translation, this review synthesises how integrating 3D bioprinting with nanotechnology yields a physiologically relevant platform for evaluating anticancer agents, probing drug-resistance mechanisms, and building patient-specific therapeutic models. This combinatorial method has a substantial improvement on precision oncology in relation to the traditional two-dimensional cell culture systems. Conclusion 3D bioprinting and nanomedicine have great potential to expedite clinical adoption of personalized lung cancer treatment, but issues of vascularization, scale, and regulatory standardization need to be overcome.

Source: Next Nanotechnology

DOI: 10.1016/j.nxnano.2026.100796

Authors: Hardik Rana, Khushi Patel, Mansi Dholakia, Vaishali Thakkar, Tejal Gandhi

Institution: Dharmsinh Desai University

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,280