Supplemental Material for: Localized intestinal amyloidosis case report – uncommon presentation of a rare disease
Year: 2026
Type: supplementary-materials
Abstract: Introduction: Amyloidosis involves a heterogeneous group of diseases resulting from extracellular deposition of abnormal fibrillar proteins. Systemic and localized forms of the disease are recognized, with distinct presentations and prognoses.Case presentation: We report the case of a 70-year-old male with a history of diarrhoea and weight loss. Upper gastrointestinal endoscopy revealed duodenal mucosal thickening and whitish granularity. Biopsies showed a positive Congo Red staining. Aetiological investigation was negative. Thus, localized intestinal amyloidosis was diagnosed. The patient was medicated with rifaximin and loperamide for symptomatic control.Discussion/conclusion: Gastrointestinal tract involvement in systemic amyloidosis carries a worse prognosis. Localized amyloidosis is a rarer variant of the disease, with better prognosis and no known cases of progression. Follow-up consists of symptomatic control. This highlights a rare form of amyloidosis with benign clinical course, in which invasive or aggressive treatments should be avoided.
Source: Figshare
Institution: Karger Publishers (Switzerland)
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7213999944