Work

Distal tubular hyperplasia of the kidney: a unique finding in end stage renal disease

Year: 2026

Type: article

Abstract: Distal tubular hyperplasia (DTH) is an underrecognized renal process reported in 5% of patients with end-stage renal disease (ESRD). Herein, we describe a case of 74-year-old man, with ESRD and clear cell papillary renal cell tumour with diffuse tubular distal hyperplasia to highlight this extremely rare finding. Histological examination of the tumour showed features of clear cell papillary renal cell tumour. Adjacent renal parenchyma showed multiple DTH’s foci, positive for CK7 and GATA3 with negative AMACR (alpha-methylacyl-CoA racemase) and CD10. Learning points Distal tubular hyperplasia (DTH) is a rare entity. Shed light on pathological aspects of this entity along with the finding of clear cell papillary renal cell tumour. Highlight the need for further studies to elucidate the clinical significance of distal tubular hyperplasia (DTH).

Source: Research Connections

DOI: 10.1093/rescon/vmag168

Authors: Sabrine Derqaoui, Taha Yassine Aaboudech, Siham Mesmoudi, Jahid Ahmed, Zakia Bernoussi, Kaoutar Znati

Institutions: Mohammed V University, Centre Hospitalier Ibn Sina

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000