Peptide-functionalized Nanocoatings for Prevention of Biofouling and Device-Associated Infections
Year: 2026
Type: conference-paper
Abstract: Conclusion• Indwelling medical devices are highly susceptible to microbial colonization, with bacterial adhesion and subsequent biofilm formation contributing to deviceassociated infections.• Catheter-associated urinary tract infections (CAUTIs) account for a substantial proportion of healthcare-associated infections, with approximately 75% of hospitalacquired UTIs associated with urinary catheters 1 .• Biofilm formation on device surfaces promotes persistent bacterial colonization and increases tolerance to antimicrobial treatment.• Antimicrobial peptides (AMPs) are short, cationic and amphipathic biomolecules that exhibit potent antimicrobial activity through interactions with bacterial membranes.However, properties such as proteolytic instability, rapid clearance, structural degradation and concentration-dependent cytotoxicity reduces their biomedical applicability.• Conjugation of peptides with nanomaterials results in the formation of peptide- functionalized nanoconjugates that combine the bioactivity of peptides with the physicochemical properties of nanomaterials, offering enhanced stability, surface association and biocompatibility for biomedical applications 2 . • In this study, a novel synthetic antimicrobial peptide DP1 (RFGRFLRKILRFLKK) 3 was covalently conjugated with reduced graphene oxide (rGO) to develop a peptide-functionalized nano conjugate (rGO-DP1) 4 , which was further developed as an antimicrobial and antibiofilm nanocoating for medical-device surfaces 5 .Results 38
Source: European Peptide Symposium (EPS)
Authors: Shubhi Joshi, Avneet Saini
Institutions: Rayat Bahra University, Panjab University
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7214280662