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Recent advances in metal-free functionalization of 1,4-benzoxazin-2-one scaffolds

Year: 2026
Type: review
Abstract: Transition metal free methodologies have emerged as sustainable alternatives for the functionalization of biologically important heterocylic scaffolds. Among the heterocycles 1,4-benzoxazin-2-one has attracted considerable interest owing to its diverse pharmaceutical and agrochemical applications. In this review, we summarize the recent advances in the transition metal-free functionalization of 1,4-benzoxazin-2-one, highlighting the organocatalytic transformations, main group Lewis acid/base promoted reactions, visible-light mediated and ultrasound assisted multicomponent reactions. Special emphasis is given to methodologies that enable the efficient synthesis of biologically active 1,4-benzoxazin-2-one derivatives. The reaction scope, mechanistic aspect, regio and stereoselectivity, and synthetic applications of these methodologies are critically discussed to provide a comprehensive overview of this rapidly developing area.
Source: RSC Advances
DOI: 10.1039/d6ra07157k
Authors: Ravi Kumar Thakur, Karunesh Keshav, Om P. S. Patel, Goverdhan Vyas, Abadh Kishor Jha, Rangnath Ravi, Shanakar Kumar, Mukesh Kumar Tyagi
Institutions: Veer Kunwar Singh University, Maharshi Vishwamitra College, Buxar, Munger University, Patna University, Hemchand Yadav Vishwavidyalaya, University of Delhi
Language: English
Field: Chemistry
Open Access status: gold
Estimated APC paid: $1,042
OpenAlex ID: W7214286192
FWCI:
Cites: 49
Cited by:
Related to: 10